Genomewide SNP Screen to Detect Quantitative Trait Loci for Alcohol Preference in the High Alcohol Preferring and Low Alcohol Preferring Mice
نویسندگان
چکیده
منابع مشابه
Alcohol place preference conditioning in high- and low-alcohol preferring selected lines of mice.
High- and low-alcohol preferring (HAP and LAP) selected lines of mice diverge greatly in free-choice alcohol consumption. This study investigated whether the lines differ in a measure of alcohol reward not dependent on drinking, specifically place conditioning. Mice were subjected to a differential conditioning procedure in which four alcohol-paired CS+ trials on one floor cue (0, 1.5, 3, or 4 ...
متن کاملHigh-alcohol preferring mice are more impulsive than low-alcohol preferring mice as measured in the delay discounting task.
BACKGROUND Repeated studies have shown that high impulsivity, when defined as the tendency to choose small immediate rewards over larger delayed rewards, is more prevalent in drug addicts and alcoholics when compared with nonaddicts. Assessing whether impulsivity precedes and potentially causes addiction disorders is difficult in humans because they all share a history of drug use. In this stud...
متن کاملEffects of cross-fostering on alcohol preference and correlated responses to selection in high- and low-alcohol-preferring mice.
BACKGROUND Selectively bred rodent lines are valuable tools for investigating gene × environment interactions related to risk for alcoholism in humans. Early maternal environment is one particular factor known for critically influencing neural, hormonal, and behavioral outcomes in adulthood. Cross-fostering is a procedure that may be used to explore the role of genotype-dependent maternal influ...
متن کاملTryptophan metabolism in male Sardinian alcohol-preferring (sP) and -non-preferring (sNP) rats.
Parameters of tryptophan (Trp) and related metabolism were compared in male Sardinian alcohol-preferring (sP) and -non-preferring (sNP) rats. Liver Trp pyrrolase activity was 38-58% higher in sP than in sNP rats, and this was associated with a greater expression of the enzyme mRNA as measured by multiprobe oligonucleotide solution hybridization. Moderately (about 10-19%), but significantly, low...
متن کاملDrinking of flavored solutions by high preferring (WHP) and low preferring (WLP) alcohol-drinking rats.
BACKGROUND Selective breeding alcohol-preferring (P) and alcohol-nonpreferring (NP) rats showed a strong preference for the sucrose solutions, whereas P rats intake greater amounts than NP rats. The aim of this study was the estimation of selectively bred ethanol-preferring (WHP - Warsaw High Preferring) and ethanol-nonpreferring (WLP - Warsaw Low Preferring) rats for their preference for vario...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Alcoholism: Clinical and Experimental Research
سال: 2009
ISSN: 0145-6008,1530-0277
DOI: 10.1111/j.1530-0277.2008.00866.x